Pure food grade silicone will have no ill effects to humans.
There is more likely to be a CO2 issue with a single hose, after all, your rebreathing about a cup of used air each breath. The facts are that with either a double hose or a single hose CO2 poisoning is highly unlikely and probably impossible and not a concern.
Well, impossible, well, there are people who can accomplish anything.
Nemrod